PHCentral RSS - rss http://phcentral.org FIRE feed Sat, 28 Mar 2015 23:03:52 GMT Why Dietary Cholesterol Is No Longer Enemy Number One http://www.phcentral.org/news/5658 http://www.medscape.com/viewarticle/841486 March 29, 2015 Observing Alterations on Right Side of Heart Reveals COPD-Related PH Best http://www.phcentral.org/news/5657 http://pulmonaryhypertensionnews.com/2015/03/17/copd-related-ph-is-better-detected-looking-at-right-sided-heart-alterations/ March 29, 2015 Egyptian Journal of Chest Diseases and Tuberculosis suggest that Pulmonary hypertension (PH) in patients with Chronic Obstructive Pulmonary Disease (COPD) is a common co-morbidity along with right sided cardiac changes. Based on the findings, the researchers suggest that Echocardiography should be used with caution during assessment of pulmonary artery systolic pressure (PASP). In the study, COPDPH patients were also found to have worse prognosis than COPD patients without PH.]]> Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of PAH http://www.phcentral.org/news/5656 http://www.medscape.com/viewarticle/840993 March 28, 2015 Iron Homeostasis and Pulmonary Hypertension http://www.phcentral.org/news/5655 http://circres.ahajournals.org/content/early/2015/03/12/CIRCRESAHA.116.305265.abstract March 28, 2015 Researchers Uncover a Potential Non-invasive Test for Certain Types of Pulmonary Hypertension http://www.phcentral.org/news/5654 http://pulmonaryhypertensionnews.com/2015/03/26/researchers-uncover-a-potential-non-invasive-test-for-certain-types-of-pulmonary-hypertension/ March 27, 2015 Pulmonary arterial hypertension associated with chronic active Epstein-Barr virus infection. http://www.phcentral.org/news/5653 http://www.ncbi.nlm.nih.gov/pubmed/25809637 March 27, 2015 Beneficial Effects of Renal Denervation on Pulmonary Vascular Remodeling in Experimental Pulmonary Artery Hypertension. http://www.phcentral.org/news/5652 http://www.ncbi.nlm.nih.gov/pubmed/25804321 March 26, 2015 [..]
Renal denervation attenuates pulmonary vascular remodeling and decreases pulmonary arterial pressure in experimental pulmonary arterial hypertension. The effect of renal denervation may contribute to decreased neurohormone levels.]]>
Reported sildenafil side effects in pediatric pulmonary hypertension patients. http://www.phcentral.org/news/5651 http://www.ncbi.nlm.nih.gov/pubmed/25806361 March 26, 2015 Bellerophon Therapeutics Selects Flextronics to Manufacture the Mark2, Next-Generation INOpulse(R) Device http://www.phcentral.org/news/5650 http://money.cnn.com/news/newsfeeds/articles/globenewswire/10126252.htm March 25, 2015
Jonathan Peacock, Chairman and Chief Executive Officer of Bellerophon Therapeutics, noted, "We are pleased to work with Flextronics, an established, global leader, for the manufacturing of our next-generation device. This new device is significantly smaller, lighter and more user friendly than the previous version, which we believe will help patients to be more compliant with their therapy. Flextronics' experience with manufacturing medical devices, including portable drug delivery systems, was important to us, and we look forward to working with them to have devices ready for our upcoming Phase 3 trials for the treatment of pulmonary arterial hypertension (PAH) which we expect to commence in the second half of 2015."]]>
Cystic Fibrosis Discovery Provides Insight into Other Pulmonary Conditions - See more at: http://www.hcplive.com/news/Cystic-Fibrosis-Discovery-Provides-Insight-into-Other-Pulmonary-Conditions#sthash.kijEQvsi.dpuf http://www.phcentral.org/news/5649 http://www.hcplive.com/news/Cystic-Fibrosis-Discovery-Provides-Insight-into-Other-Pulmonary-Conditions March 25, 2015 Risk for Anesthesia Complications Still High In Children With Pulmonary Hypertension http://www.phcentral.org/news/5648 http://www.anesthesiologynews.com/ViewArticle.aspx?d=PRN&d_id=21&i=March+2015&i_id=1156&a_id=29640 March 24, 2015 Sildenafil therapy in bronchopulmonary dysplasia-associated PH: a retrospective study of efficacy and safety http://www.phcentral.org/news/5647 http://link.springer.com/article/10.1007/s00431-015-2515-7 March 24, 2015 Prognostic potential for pericardial effusion in PAH patients http://www.phcentral.org/news/5646 http://www.news-medical.net/news/20150313/Prognostic-potential-for-pericardial-effusion-in-PAH-patients.aspx March 23, 2015 Combining CT measurements assists pulmonary hypertension prediction http://www.phcentral.org/news/5645 http://www.news-medical.net/news/20150313/Combining-CT-measurements-assists-pulmonary-hypertension-prediction.aspx March 22, 2015 Boy's 26 arterial narrowings fixed in one fell swoop http://www.phcentral.org/news/5644 http://www.healthcanal.com/blood-heart-circulation/heart-disease/61530-boy-s-26-arterial-narrowings-fixed-in-one-fell-swoop.html March 22, 2015 Selten's PAH treatment tacrolimus gets FDA orphan drug status http://www.phcentral.org/news/5643 http://regulatoryaffairs.pharmaceutical-business-review.com/news/seltens-pah-treatment-tacrolimus-gets-fda-orphan-drug-status-190315-4535781 March 21, 2015 Issues remain in treatment diagnosis of PH in patients with inflammatory rheumatic diseases http://www.phcentral.org/news/5642 http://www.healio.com/rheumatology/lupus/news/online/{66679395-1732-4cd7-a68e-4edb23bd68d3}/issues-remain-in-treatment-diagnosis-of-ph-in-patients-with-inflammatory-rheumatic-diseases?sc_trk=internalsearch March 21, 2015 New Cellular Proliferation Protein Observed in Idiopathic Pulmonary Arterial Hypertension http://www.phcentral.org/news/5641 http://pulmonaryhypertensionnews.com/2015/03/18/new-cellular-proliferation-protein-observed-in-idiopathic-pulmonary-arterial-hypertension/ March 20, 2015 Computed Tomography Pulmonary Angiography Measurements Shown as a Predictive Tool for Pulmonary Hypertension http://www.phcentral.org/news/5640 http://lungdiseasenews.com/2015/03/19/computed-tomography-pulmonary-angiography-measurements-shown-as-a-predictive-tool-for-pulmonary-hypertension/ March 20, 2015 COPD Patients with Pulmonary Hypertension are More Prone to Co-Morbidities http://www.phcentral.org/news/5638 http://lungdiseasenews.com/2015/03/16/copd-patients-with-pulmonary-hypertension-are-more-prone-to-co-morbidities/ March 19, 2015 Small Study Suggests Benefits of Denervation for PAH http://www.phcentral.org/news/5639 http://www.tctmd.com/txshow.aspx?id=128259&trid=858500 March 19, 2015 Procedure appears to improve functional, hemodynamic outcomes.


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Pulmokine Receives $1M Investment to Further PAH Drug Development http://www.phcentral.org/news/5637 http://pulmonaryhypertensionnews.com/2015/03/16/pulmokine-receives-1m-investment-to-further-pah-drug-development/ March 18, 2015 Selexipag (Uptravi) long-term outcome data in pulmonary arterial hypertension http://www.phcentral.org/news/5636 https://uk.finance.yahoo.com/news/selexipag-uptravi-long-term-outcome-193202683.html March 17, 2015 Improved Quality in Assessment of Heart Function with EchoInsight http://www.phcentral.org/news/5635 http://www.businesswire.com/news/home/20150315005006/en/Epsilon-Imaging-Announces-Studies-Presented-ACC-15#.VQcCoWd0y58 March 16, 2015 Discolored fingers? It could be Raynaud’s phenomenon http://www.phcentral.org/news/5634 http://www.courierpostonline.com/story/life/2015/03/16/discolored-fingers-raynauds-phenomenon/24834457/ March 16, 2015 ]]> Idiopathic Pulmonary Fibrosis Outcomes Improved With Need-Based Allocation And Double Lung Transplants http://www.phcentral.org/news/5633 http://pulmonaryfibrosisnews.com/2015/03/04/idiopathic-pulmonary-fibrosis-outcomes-improved-with-need-based-allocation-and-double-lung-transplants/ March 15, 2015 Journal of the American Medical Association (JAMA) finds that a medical need-based donor lung allocation protocol has been associated with better graft survival than single-lung transplantation procedures in persons afflicted with idiopathic pulmonary fibrosis (IPF).]]> Individual CTEPH Case Study Demonstrates Features of Heart Failure http://www.phcentral.org/news/5632 http://pulmonaryhypertensionnews.com/2015/03/10/individual-cteph-case-study-demonstrates-features-of-heart-failure/ March 15, 2015 Researchers Review Importance of Non-Invasive Imaging in Diagnosis and Management of PAH http://www.phcentral.org/news/5631 http://lungdiseasenews.com/2015/03/10/researchers-review-importance-of-non-invasive-imaging-in-diagnosis-and-management-of-pah/ March 14, 2015 Canadian Journal of Cardiology, an open access journal, provides an overview of the current clinical use of noninvasive imagining techniques, such as echocardiography, for pulmonary arterial hypertension (PAH). The study investigators, led by Dr. Irene Lang, MD, Professorship of Vascular Biology, Department of Internal Medicine, Division of Cardiology, Medical University of Vienna Austria, conducted a thoroughly researched review that highlights the present role non-invasive imaging has and its potential to eventually replace hemodynamics as the standard approach to screening, diagnosing and managing PAH.]]> Results of SERAPHIN Trial Show Macitentan PAH Treatment Decreases Hospitalization Risk http://www.phcentral.org/news/5630 http://lungdiseasenews.com/2015/03/09/results-of-seraphin-trial-show-macitentan-pah-treatment-decreases-hospitalization-risk/ March 14, 2015 Heart Failure, a journal of the American College of Cardiologists.]]> The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. http://www.phcentral.org/news/5629 http://www.ncbi.nlm.nih.gov/pubmed/25761906 March 13, 2015 Study Reveals Stark Differences Between Medicare Advantage, Commercially Insured PAH Patients’ Healthcare Costs http://www.phcentral.org/news/5628 http://pulmonaryhypertensionnews.com/2015/03/12/study-reveals-stark-differences-between-medicare-advantage-commercially-insured-pah-patients-healthcare-costs/ March 12, 2015 Meta Anaylsis shows improved survival and hospitalisation in pulmonary arterial hypertension http://www.phcentral.org/news/5627 http://www.aerztezeitung.de/medizin/krankheiten/herzkreislauf/bluthochdruck/article/880148/therapiefortschritte-tut-pulmonaler-hypertonie.html March 12, 2015 Metabolic dysfunction in pulmonary arterial hypertension. http://www.phcentral.org/news/5626 http://link.springer.com/article/10.1007/s11906-014-0524-y March 12, 2015 FDA Clears Corbus’ IND to Start Phase 2 Scleroderma Treatment Study http://www.phcentral.org/news/5625 http://pulmonaryhypertensionnews.com/2015/03/11/fda-clears-corbus-ind-to-start-phase-2-scleroderma-treatment-study/ March 11, 2015 Capillary pCO2 helps distinguishing idiopathic pulmonary arterial hypertension from pulmonary hypertension due to heart failure with preserved ejection fraction http://www.phcentral.org/news/5624 http://7thspace.com/headlines/504911/capillary_pco2_helps_distinguishing_idiopathic_pulmonary_arterial_hypertension_from_pulmonary_hypertension_due_to_heart_failure_with_preserved_ejection_fraction.html March 11, 2015 ]]> Leptin signalling system as a target for pulmonary arterial hypertension therapy. http://www.phcentral.org/news/5622 http://erj.ersjournals.com/content/early/2015/03/05/09031936.00193014.1.abstract March 10, 2015 Capillary pCO2 helps distinguishing idiopathic pulmonary arterial hypertension from pulmonary hypertension due to heart failure with preserved ejection fraction http://www.phcentral.org/news/5623 http://7thspace.com/headlines/504911/capillary_pco2_helps_distinguishing_idiopathic_pulmonary_arterial_hypertension_from_pulmonary_hypertension_due_to_heart_failure_with_preserved_ejection_fraction.html March 10, 2015 Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension. http://www.phcentral.org/news/5621 http://atvb.ahajournals.org/content/early/2015/03/05/ATVBAHA.114.304864.abstract March 9, 2015 Pulmokine Receives $1 Million Investment from Broadview Ventures to Advance PAH Candidate into First Clinical Trial http://www.phcentral.org/news/5620 http://globenewswire.com/news-release/2015/03/03/711819/10122955/en/Pulmokine-Receives-1-Million-Investment-from-Broadview-Ventures-to-Advance-PAH-Candidate-into-First-Clinical-Trial.html March 8, 2015 Scimitar syndrome with absent right pulmonary artery and severe pulmonary hypertension treated with coil occlusion of aortopulmonary collaterals in a term neonate http://www.phcentral.org/news/5619 http://casereports.bmj.com/content/2015/bcr-2014-208743.short?rss=1 March 8, 2015 Langerhans Cell Histiocytosis-Related PH Benefits from Advanced Therapies, According to Individual Case Study http://www.phcentral.org/news/5617 http://pulmonaryhypertensionnews.com/2015/03/05/langerhans-cell-histiocytosis-related-ph-benefits-from-advanced-therapies/ March 7, 2015 Enhancing and Inhibiting Autophagy in Lung Disease is Double-Edged http://www.phcentral.org/news/5618 http://lungdiseasenews.com/2015/03/02/enhancing-and-inhibiting-autophagy-in-lung-disease-is-double-edged/ March 7, 2015 UCSF Liver Transplant Conference 2014: Porto-Pulmonary Hypertension http://www.phcentral.org/news/5610 http://www.uctv.tv/shows/UCSF-Liver-Transplant-Conference-2014-Porto-Pulmonary-Hypertension-29266 March 6, 2015 Van Selby, MD discusses elevated pulmonary artery pressures due to increased resistance to blood flow in the setting of portal hypertension. The effects on and from liver transplantation are detailed.]]> Pulmonary hypertension frequent comorbidity in patients with aortic stenosis undergoing TAVR http://www.phcentral.org/news/5615 http://www.healio.com/cardiology/intervention/news/online/{a4a65711-5b5b-4ba1-9176-266b921029ca}/pulmonary-hypertension-frequent-comorbidity-in-patients-with-aortic-stenosis-undergoing-tavr?sc_trk=internalsearch March 6, 2015 Outcomes of lung transplantations since implementation of need-based allocation system http://www.phcentral.org/news/5614 http://medicalxpress.com/news/2015-03-outcomes-lung-transplantations-need-based-allocation.html March 6, 2015 Canadians with rare, complex and fatal lung disease fearful of one-size-fits-all approach to treatment http://www.phcentral.org/news/5616 http://www.newswire.ca/en/story/1497445/canadians-with-rare-complex-and-fatal-lung-disease-fearful-of-one-size-fits-all-approach-to-treatment March 6, 2015 Pulmonary hypertension frequent comorbidity in patients with aortic stenosis undergoing TAVR http://www.phcentral.org/news/5609 http://www.healio.com/cardiology/intervention/news/online/{a4a65711-5b5b-4ba1-9176-266b921029ca}/pulmonary-hypertension-frequent-comorbidity-in-patients-with-aortic-stenosis-undergoing-tavr?sc_trk=internalsearch March 5, 2015 Actelion's New Drug Application for selexipag (Uptravi) is accepted by the US FDA with a standard review time http://www.phcentral.org/news/5613 http://www.nasdaq.com/press-release/actelions-new-drug-application-for-selexipag-uptravi-is-accepted-by-the-us-fda-with-a-standard-20150303-00949 March 5, 2015 Diagnosis, Management of PAH Benefit From Non-invasive Imaging Methods, According to Study http://www.phcentral.org/news/5612 http://pulmonaryhypertensionnews.com/2015/03/03/diagnosis-management-of-pah-benefit-from-non-invasive-imaging-methods-according-to-study/ March 5, 2015 Selexipag (Uptravi) data in pulmonary arterial hypertension to be presented at American College of Cardiology (ACC) 2015 http://www.phcentral.org/news/5608 http://www.nasdaq.com/press-release/selexipag-uptravi-data-in-pulmonary-arterial-hypertension-to-be-presented-at-american-college-of-20150302-00667 March 4, 2015
http://www.abstractsonline.com/pp8/#!/3658/presentation/29719


Read more: http://www.nasdaq.com/press-release/selexipag-uptravi-data-in-pulmonary-arterial-hypertension-to-be-presented-at-american-college-of-20150302-00667#ixzz3TOLVmem6]]>
25 years of lung transplantation: "Second wind" from Vienna http://www.phcentral.org/news/5607 http://www.healthcanal.com/lungs-breathing/60851-25-years-of-lung-transplantation-second-wind-from-vienna.html March 3, 2015 Beta Blocker Nebivolol Shows Promise In Pulmonary Arterial Hypertension http://www.phcentral.org/news/5606 http://pulmonaryhypertensionnews.com/2015/03/02/beta-blocker-nebivolol-shows-promise-in-pulmonary-arterial-hypertension/ March 3, 2015 UAB offers pulmonary medicine research symposium http://www.phcentral.org/news/5611 http://www.uab.edu/news/faculty/item/5776-uab-offers-pulmonary-medicine-research-symposium-and-clinical-care-update March 2, 2015
Topics covered include risk factors, pathogenesis and management of COPD, asthma, ARDS and pulmonary hypertension.]]>
Why Heart Rate Matters http://www.phcentral.org/news/5605 http://www.heartratematters.com/why-heart-rate-matters/ March 2, 2015 ≥19% INCREASE in the risk of all-cause mortality in patients with left ventricular dysfunction (LVEF ≤ 40%)
≥25% INCREASE in the risk of the composite outcome of CV death or hospital stay for worsening HF in patients with left ventricular dysfunction (LVEF ≤ 40%)]]>
Role for Telomerase in Pulmonary Hypertension http://www.phcentral.org/news/5604 http://circ.ahajournals.org/content/131/8/742.full March 1, 2015 SteadyMed Raises $12.2M to Advance PAH Therapy http://www.phcentral.org/news/5603 http://pulmonaryhypertensionnews.com/2015/02/19/steadymed-raises-12-2m-to-advance-pah-therapy/ March 1, 2015 CDC Says Influenza Vaccine Only 18% Effective This Year http://www.phcentral.org/news/5602 http://www.medscape.com/viewarticle/840557 February 28, 2015 Adempas Approved in Japan for the Treatment of Pulmonary Arterial Hypertension http://www.phcentral.org/news/5601 http://www.finchannel.com/index.php/component/k2/item/40342-adempas-approved-in-japan-for-the-treatment-of-pulmonary-arterial-hypertension February 28, 2015