PHCentral RSS - rss http://phcentral.org FIRE feed Wed, 28 Jan 2015 20:01:42 GMT Concentric remodelling preserves right ventricular function in PAH http://www.phcentral.org/news/5559 http://www.news-medical.net/news/20150116/Concentric-remodelling-preserves-right-ventricular-function-in-PAH.aspx January 30, 2015 SERAPHIN: Macitentan linked to decreased hospitalization risk http://www.phcentral.org/news/5558 http://www.healio.com/cardiology/vascular-medicine/news/online/{9b934593-7f30-4102-b8ff-c9e2c6b34e11}/seraphin-macitentan-linked-to-decreased-hospitalization-risk January 29, 2015 Why Sleep Soothes The Flu http://www.phcentral.org/news/5554 http://www.insidescience.org/content/why-sleep-soothes-flu/2511 January 28, 2015 Takayasu Arteritis-associated Pulmonary Hypertension http://www.phcentral.org/news/5557 http://jrheum.org/content/early/2015/01/07/jrheum.140436.abstract January 28, 2015 A comparison of the predictive accuracy of three screening models for AH in systemic sclerosis http://www.phcentral.org/news/5556 http://7thspace.com/headlines/502633/a_comparison_of_the_predictive_accuracy_of_three_screening_models_for_pulmonary_arterial_hypertension_in_systemic_sclerosis.html January 27, 2015 Peripheral muscles weakened in PAH patients http://www.phcentral.org/news/5555 http://www.news-medical.net/news/20150116/Peripheral-muscles-weakened-in-PAH-patients.aspx January 26, 2015 The Flavonoid Quercetin Reverses Pulmonary Hypertension in Rats http://www.phcentral.org/news/5553 http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0114492 January 25, 2015 Idiopathic PA Hypertension Responds Variably to Vasodilators http://www.phcentral.org/news/5552 http://www.medscape.com/viewarticle/838439 January 25, 2015
"Not all patients with seeming IPAH are alike," Dr. David Langleben, of McGill University, Montreal, Quebec, told Reuters Health by email. "The acute vasodilator responders are a truly distinct group. This group should probably be a separate subcategory in the classification of IPAH."]]>
CT measures can refine PAH prognosis http://www.phcentral.org/news/5551 http://www.news-medical.net/news/20150116/CT-measures-can-refine-PAH-prognosis.aspx January 24, 2015 Early Screening Methods for Pulmonary Arterial Hypertension in Systemic Sclerosis Evaluated in New Study http://www.phcentral.org/news/5550 http://pulmonaryhypertensionnews.com/2015/01/19/early-screening-methods-for-pulmonary-arterial-hypertension-in-systemic-sclerosis-evaluated-in-new-study/ January 24, 2015 Arthritis Research & Therapy.]]> New Treatments Haven't Lowered Anesthesia Risks for Children with Pulmonary Hypertension http://www.phcentral.org/news/5549 http://www.newswise.com/articles/new-treatments-haven-t-lowered-anesthesia-risks-for-children-with-pulmonary-hypertension-reports-anesthesia-analgesia January 23, 2015 Asthma Linked to New-Onset Sleep Apnea http://www.phcentral.org/news/5547 http://www.medscape.com/viewarticle/838114 January 21, 2015 Seasonal Influenza Vaccine Only 23% Effective This Year http://www.phcentral.org/news/5546 http://www.medscape.com/viewarticle/838241 January 20, 2015 Ascendis to Start Phase 1 Study of PAH Treatment http://www.phcentral.org/news/5545 http://pulmonaryhypertensionnews.com/2015/01/15/ascendis-to-start-phase-1-study-of-pah-treatment/ January 19, 2015 Notch Activation of Ca2+ Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension. http://www.phcentral.org/news/5544 http://www.ncbi.nlm.nih.gov/pubmed/25569851 January 18, 2015 Pacific Therapeutics CEO Provides Updates About Therapy For Idiopathic Pulmonary Fibrosis http://www.phcentral.org/news/5543 http://pulmonaryhypertensionnews.com/2015/01/09/pacific-therapeutics-ceo-provides-updates-about-therapy-for-idiopathic-pulmonary-fibrosis/ January 18, 2015 Bellerophon Therapeutics (BLPH) Files $69M IPO http://www.phcentral.org/news/5542 http://www.streetinsider.com/IPOs/Bellerophon+Therapeutics+(BLPH)+Files+$69M+IPO/10162123.html January 18, 2015 Effects of Epoprostenol on Right Ventricular Hypertrophy and Dilatation in Pulmonary Hypertension http://www.phcentral.org/news/5541 http://life-without-diseases.com/effects-of-epoprostenol-on-right-ventricular-hypertrophy-and-dilatation-in-pulmonary-hypertension.html January 17, 2015 Exercise Pathophysiology in Patients With Primary Pulmonary Hypertension http://www.phcentral.org/news/5540 http://circ.ahajournals.org/content/104/4/429.full January 17, 2015 Pulmonary Arterial Hypertension Medications Studied for Drug Interactions http://www.phcentral.org/news/5538 http://pulmonaryhypertensionnews.com/2015/01/14/pulmonary-arterial-hypertension-medications-studied-for-drug-interactions/ January 16, 2015 Pulmonary hypertension in idiopathic pulmonary fibrosis does not influence six-minute walk distance http://www.phcentral.org/news/5539 http://www.ncbi.nlm.nih.gov/pubmed/25591141 January 16, 2015 [..]
Conclusions: Our data suggested that 6MWD does not differ between IPF patients with or without PH. Thus, 6MWD should not be used as a surrogate endpoint in clinical study in patients affected by IPF and PH.]]>
Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model. http://www.phcentral.org/news/5537 http://www.ncbi.nlm.nih.gov/pubmed/25587286 January 15, 2015 Ascendis Pharma A/S Announces Initiation of a Phase 1 Single Ascending Dose Study of TransCon Treprostinil http://www.phcentral.org/news/5536 http://www.prnewswire.com/news-releases/ascendis-pharma-as-announces-initiation-of-a-phase-1-single-ascending-dose-study-of-transcon-treprostinil-300020394.html January 14, 2015
TransCon Treprostinil has been designed as an inert prodrug that enables a sustained release of unmodified treprostinil in circulation following a once-daily self-administered subcutaneous injection. TransCon Treprostinil is intended to produce a pharmacokinetic profile comparable to continuously infused prostacyclins, with the benefit of a more convenient route of administration, while avoiding the infusion site pain and risk of bloodstream infections associated with currently marketed infused prostacyclin therapies...]]>
Survival of adults with systemic sclerosis following lung transplantation: A nationwide cohort study. http://www.phcentral.org/news/5535 http://www.ncbi.nlm.nih.gov/pubmed/25581250 January 14, 2015 Pharmacokinetic interactions among imatinib, bosentan and sildenafil, and their clinical implications in severe pulmonary arterial hypertension. http://www.phcentral.org/news/5534 http://www.ncbi.nlm.nih.gov/pubmed/25581063 January 13, 2015
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Arena Pharmaceuticals Initiates Phase 2 Clinical Trial Evaluating Ralinepag for Pulmonary Arterial Hypertension http://www.phcentral.org/news/5533 http://pipelinereview.com/index.php/2015011256632/Small-Molecules/Arena-Pharmaceuticals-Initiates-Phase-2-Clinical-Trial-Evaluating-Ralinepag-for-Pulmonary-Arterial-Hypertension.html January 12, 2015
"An intriguing component of this compound is the smooth peak-to-trough ratio, which may potentiate efficacy and minimize toxicity relative to currently available therapies," said Lewis J. Rubin, M.D., Emeritus Professor of Medicine at University of California, San Diego, School of Medicine. "This clinical trial should help to further elucidate how ralinepag's intrinsic properties translate to its efficacy and safety profile."

This 22-week, randomized, double-blind and placebo-controlled Phase 2 trial will..]]>
Pulmonary Hypertension in Chronic Lung Diseases http://www.phcentral.org/news/5532 http://content.onlinejacc.org/article.aspx?articleID=1790606 January 11, 2015 Role of BNP and Echo measurement for pulmonary hypertension recognition in patients with interstitial lung disease: an algorithm application model http://www.phcentral.org/news/5531 http://www.resmedjournal.com/article/S0954-6111(14)00449-1/abstract January 11, 2015 United Therapeutics and DEKA Sign Agreement for New PAH Remodulin Delivery System http://www.phcentral.org/news/5530 http://pulmonaryhypertensionnews.com/2015/01/02/united-therapeutics-and-deka-sign-agreement-for-new-pah-remodulin-delivery-system/ January 10, 2015 Modified Potts Shunt in an adult with pulmonary arterial hypertension and recurrent syncope – three-year follow-up http://www.phcentral.org/news/5529 http://www.internationaljournalofcardiology.com/article/S0167-5273(15)00034-0/abstract January 10, 2015 Flu Season 2015: Influenza In US ‘Widespread,’ But Fear May Outpace Threat http://www.phcentral.org/news/5528 http://www.ibtimes.com/flu-season-2015-influenza-us-widespread-fear-may-outpace-threat-1776348 January 8, 2015 Could a National PH Registry Improve Research and Treatment in America? http://www.phcentral.org/news/5527 http://pulmonaryhypertensionnews.com/2015/01/05/first-results-from-a-national-registry-for-pulmonary-hypertension-in-russia/ January 7, 2015 Health Talk: Know the signs and symptoms of COPD http://www.phcentral.org/news/5526 http://www.capitalgazette.com/lifestyle/health/ph-ac-gn-health-talk-0107-20150105,0,5417500.story January 6, 2015 Pulmonary Arterial Hypertension in the US: How Much Does it Cost? http://www.phcentral.org/news/5525 http://pulmonaryhypertensionnews.com/2014/12/29/pulmonary-arterial-hypertension-in-the-us-how-much-does-it-cost/ January 5, 2015 Medtronic Submits Drug Delivery System to FDA to Complement United Therapeutics’ PAH Treatment http://www.phcentral.org/news/5524 http://lungdiseasenews.com/2014/12/29/medtronic-submits-drug-delivery-system-to-fda-to-complement-united-therapeutics-pah-treatment/ January 4, 2015 Diagnosis, Assessment, and Treatment of Non-Pulmonary Arterial Hypertension Pulmonary Hypertension http://www.phcentral.org/news/5523 https://www.google.com/url?rct=j&sa=t&url=http://www.researchgate.net/publication/51437095_Diagnosis_assessment_and_treatment_of_non-pulmonary_arterial_hypertension_pulmonary_hypertension/links/00b49526ab193bb479000000.pdf&ct=ga&cd=CAEYACoSNDU4MzgxMjc3MTAzMjMwNTQ5Mho0ODQwMmEzNzI4OWIyYzRlOmNvbTplbjpVUw&usg=AFQjCNErWnyhppPv37J8rsNP7h2cHn5vvQ January 4, 2015 Actelion Submits New Drug for Pulmonary Arterial Hypertension to FDA http://www.phcentral.org/news/5522 http://lungdiseasenews.com/2014/12/30/actelion-submits-new-drug-for-pulmonary-arterial-hypertension-to-fda/ January 3, 2015 Absence of the calcium-binding protein, S100A1, confers pulmonary hypertension in mice associated with endothelial dysfunction and apoptosis http://www.phcentral.org/news/5521 http://cardiovascres.oxfordjournals.org/content/cardiovascres/105/1/8.full.pdf January 3, 2015