PHCentral RSS - rss http://phcentral.org FIRE feed Sat, 23 Aug 2014 11:08:34 GMT A Novel Adipocytokine, Omentin, Inhibits Monocrotaline-Induced Pulmonary Arterial Hypertension In Rats http://www.phcentral.org/news/5302 http://www.sciencedirect.com/science/article/pii/S0006291X14014934 August 22, 2014 [..]
Chronic omentin treatment inhibited MCT-induced increases in PA pressure. Omentin inhibited MCT-induced right ventricular hypertrophy as well as increase of lung to body weight ratio. Histologically, omentin inhibited MCT-induced PA hyperplasia. Further, omentin inhibited the impairment of both endothelium-dependent and -independent relaxations mediated by acetylcholine and sodium nitroprusside, respectively. In conclusion, we for the first time demonstrate that chronic omentin treatment inhibits MCT-induced PAH in rats via inhibiting vascular structural remodeling and abnormal contractile reactivity.


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Effects of Bisoprolol and Losartan Treatment in the Hypertrophic and Failing Right Heart. http://www.phcentral.org/news/5301 http://www.onlinejcf.com/article/S1071-9164(14)01128-2/abstract August 21, 2014 The researchers stated: " In our PTB-model of pressure overload induced RV hypertrophy and failure, treatment with bisoprolol and losartan did not demonstrate any beneficial effects in compensated or decompensated RV failure."]]> Endothelin@25 - new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12. http://www.phcentral.org/news/5300 http://onlinelibrary.wiley.com/doi/10.1111/bph.12874/abstract;jsessionid=FC357BE55C3A84537439E23637A7F026.f02t03 August 20, 2014 Novel Mechanisms of Sildenafil in Pulmonary Hypertension Involving Cytokines/Chemokines, MAP Kinases and Akt. http://www.phcentral.org/news/5299 http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0104890&representation=PDF August 20, 2014 Obituary: Dame Julia Polak DBE http://www.phcentral.org/news/5298 http://www.pvri.info/content/obituary-dame-julia-polak-dbe#.U_PF1MXK5tB August 19, 2014 Really worth reading.  ]]> Boehringer Ingelheim Announces U.S. Filing for the Fixed-Dose Combination Tiotropium Plus Olodaterol for Patients with COPD http://www.phcentral.org/news/5297 http://www.marketwatch.com/story/boehringer-ingelheim-announces-us-filing-for-the-fixed-dose-combination-tiotropium-plus-olodaterol-for-patients-with-copd-2014-08-19 August 19, 2014
Tiotropium + olodaterol FDC is an investigational treatment consisting of the long-acting muscarinic antagonist (LAMA) tiotropium and the long-acting beta agonist (LABA) olodaterol, and is being evaluated for once-daily use via the Respimat® inhaler. The Respimat® inhaler is a propellant-free inhaler that generates a slow-moving mist.]]>
New Obstructive Sleep Apnea (OSA) Diagnosis Guidelines http://www.phcentral.org/news/5296 http://www.medscape.com/viewarticle/829717?nlid=63372_564&src=wnl_edit_medp_pulm&spon=13 August 19, 2014
However, these recommendations for diagnosing obstructive sleep apnea (OSA), based in part on a literature search, are weak, and the quality of the evidence was graded as low or moderate, according to the authors...]]>
Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with PAH http://www.phcentral.org/news/5295 http://www.ncbi.nlm.nih.gov/pubmed/25125498 August 18, 2014 New Clues From Heart Imaging Give Researchers Insight Into PH http://www.phcentral.org/news/5294 http://pulmonaryhypertensionnews.com/2014/08/14/new-clues-from-heart-imaging-give-researchers-insight-into-ph/ August 18, 2014 Playing the harmonica for health http://www.phcentral.org/news/5293 http://www.stltoday.com/lifestyles/health-med-fit/health/playing-the-harmonica-for-health/article_251852cf-0d73-53a0-8593-b53e4d5819b6.html August 17, 2014 Paediatric PAH treatment goals identified http://www.phcentral.org/news/5292 http://www.medwirenews.com/38/105810/Cardiology/Paediatric_PAH_treatment_goals_identified.html August 16, 2014 Left Ventricle Function Before and After CTEPH-Associated Surgery Assessed In New Study http://www.phcentral.org/news/5291 http://pulmonaryhypertensionnews.com/2014/08/13/left-ventricle-function-before-and-after-cteph-associated-surgery-assessed-in-new-study/ August 16, 2014 Oldies Can Be Goodies: ERA Macitentan Effective in Treating PAH During Unique Trial http://www.phcentral.org/news/5288 http://pulmonaryhypertensionnews.com/2014/08/07/oldies-can-be-goodies-era-macitentan-effective-in-treating-pah-during-unique-trial/ August 15, 2014 Pulmonary Hypertension & Pulmonary Arterial Hypertension: Categories, Risk Factors And Treatments Profiled http://www.phcentral.org/news/5287 http://pulmonaryhypertensionnews.com/2014/08/06/pulmonary-hypertension-pulmonary-arterial-hypertension-categories-risk-factors-and-treatments-profiled/ August 14, 2014 CHEST Posts Free to View Version of PAH Guidelines for Clinicians http://www.phcentral.org/news/5286 http://pulmonaryhypertensionnews.com/2014/08/11/chest-posts-free-view-version-pulmonary-arterial-hypertension-guidelines-clinicians/ August 13, 2014 Study Shows Patients With Pulmonary Arterial Hypertension Benefit From Specialized Care Centers http://www.phcentral.org/news/5290 http://pulmonaryhypertensionnews.com/2014/08/12/study-shows-patients-pulmonary-arterial-hypertension-benefit-specialized-care-centers/ August 13, 2014 FDA approves donor lung preservation device that may result in more lung transplants http://www.phcentral.org/news/5289 http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm409488.htm August 13, 2014 How Obesity and Diet Impact COPD http://www.phcentral.org/news/5285 http://www.empr.com/how-obesity-and-diet-impact-copd/article/365596/ August 12, 2014 Does the Sea Air Have Curative Powers http://www.phcentral.org/news/5284 http://online.wsj.com/articles/does-the-sea-air-have-curative-powers-1407797285 August 12, 2014 Pulmonary Hypertension & Pulmonary Arterial Hypertension: Categories, Risk Factors And Treatments Profiled http://www.phcentral.org/news/5283 http://pulmonaryhypertensionnews.com/2014/08/06/pulmonary-hypertension-pulmonary-arterial-hypertension-categories-risk-factors-and-treatments-profiled/ August 11, 2014 TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension http://www.phcentral.org/news/5281 https://www.google.com/url?rct=j&sa=t&url=http://www.mdpi.com/2079-9721/2/3/260/pdf&ct=ga&cd=CAEYLyoTMzgyODM0NjY2MDc5MjIyMjQ0OTIaNDg0MDJhMzcyODliMmM0ZTpjb206ZW46VVM&usg=AFQjCNFq6jW7nOux_VEY3u8dhx5duhKj2A August 10, 2014 by an increase in pulmonary arterial blood pressure that is driven by a progressive vascular
remodelling of small pulmonary arterioles. We have previously reported that tumor
necrosis factor apoptosis-inducing ligand (TRAIL) protein expression is increased in
pulmonary vascular lesions and pulmonary artery smooth muscle cells (PASMC) of
patients with idiopathic PAH. The addition of recombinant TRAIL induces the
proliferation and migration of PASMCs in vitro. TRAIL is required for hypoxia-induced
pulmonary hypertension in mice, and blockade of TRAIL prevents and reduces disease
development in other rodent models of PAH.]]>
Arrhythmogenesis in Pulmonary Hypertension http://www.phcentral.org/news/5280 https://www.escholar.manchester.ac.uk/api/datastream?publicationPid=uk-ac-man-scw:227267&datastreamId=FULL-TEXT.PDF August 9, 2014 'Stem cells show promise in stroke recovery' http://www.phcentral.org/news/5282 http://www.bbc.com/news/health-28694656 August 8, 2014 ...
Infusing stem cells into the brain may help boost recovery after a stroke, according to a pilot study by Imperial College London.
Scientists believe the cells encourage new blood vessels to grow in damaged areas of the brain.
They found most patients were able to walk and look after themselves independently by the end of the trial, despite having suffered severe strokes.]]>
Discovery sheds light on how changes in lungs can hurt the heart http://www.phcentral.org/news/5279 http://medicalxpress.com/news/2013-11-discovery-lungs-heart.html#inlRlv August 7, 2014 Macitentan Effective in Treating PAH During Unique Trial http://www.phcentral.org/news/5278 http://pulmonaryhypertensionnews.com/2014/08/07/oldies-can-be-goodies-era-macitentan-effective-in-treating-pah-during-unique-trial/ August 6, 2014 Emphysema Burdens PH Patients http://www.phcentral.org/news/5277 http://pulmonaryhypertensionnews.com/2014/08/06/emphysema-burdens-ph-patients-more-than-copd-and-interstitial-lung-disease/ August 5, 2014 Early detection of chronic thromboembolic pulmonary hypertension http://www.phcentral.org/news/5276 http://pulmonaryhypertensionnews.com/2014/08/04/telephone-monitoring-programs-improve-cteph-diagnosis/ August 4, 2014 'I Feel Like I'm Suffocating' -- Defining the Experience of Breathlessness http://www.phcentral.org/news/5275 http://www.medscape.com/viewarticle/828324 August 3, 2014 Exciting IPF Treatment News Must Be Interpreted Cautiously http://www.phcentral.org/news/5274 http://www.medscape.com/viewarticle/828543#1 August 3, 2014 New England Journal of Medicine.]]> Pulmonologist Recommends PAH Patients Consult Doctors Before High Altitude Exposure http://www.phcentral.org/news/5273 http://pulmonaryhypertensionnews.com/2014/07/30/pulmonologist-recommends-pah-patients-consult-doctors-high-altitude-exposure/ August 2, 2014 African Americans Tend to Have More Severe Systemic Sclerosis-Associated PAH http://www.phcentral.org/news/5272 http://pulmonaryhypertensionnews.com/2014/07/31/african-americans-tend-severe-systemic-sclerosis-associated-pah/ August 2, 2014 Macitentan Effective in Treating PAH http://www.phcentral.org/news/5268 http://pulmonaryhypertensionnews.com/2014/07/28/macitentan-treatment-effective-pah-patients/ August 1, 2014 Rubella-Related PH Leads to Infant Mortalities http://www.phcentral.org/news/5271 http://pulmonaryhypertensionnews.com/2014/07/29/rubella-related-ph-leads-infant-mortalities/ July 31, 2014 Drugs used to treat lung disease work with the body clock http://www.phcentral.org/news/5267 http://medicalxpress.com/news/2014-07-drugs-lung-disease-body-clock.html July 30, 2014 Portopulmonary hypertension: Improved detection using CT and echocardiography in combination. http://www.phcentral.org/news/5270 http://link.springer.com/article/10.1007/s00330-014-3289-4 July 30, 2014 Treatment of pulmonary hypertension in idiopathic pulmonary fibrosis: shortfall in efficacy or trial design? http://www.phcentral.org/news/5269 http://www.dovepress.com/treatment-of-pulmonary-hypertension-in-idiopathic-pulmonary-fibrosis-s-peer-reviewed-article-DDDT July 29, 2014 The Potential for Macitentan, a New Dual Endothelin Receptor Antagonist, in the Treatment of Pulmonary Arterial Hypertension http://www.phcentral.org/news/5266 http://www.medscape.com/viewarticle/826442 July 27, 2014 Pulmonary Hypertension Is Related to Peripheral Endothelial Dysfunction in Heart Failure With Preserved Ejection Fraction http://www.phcentral.org/news/5265 http://circheartfailure.ahajournals.org/content/early/2014/07/21/CIRCHEARTFAILURE.113.000942.abstract July 27, 2014 Specialty drugs transform lives — but at a cost http://www.phcentral.org/news/5264 http://www.bostonglobe.com/lifestyle/health-wellness/2014/07/20/specialty-drugs-save-transform-lives-but-cost/MY2hxd8gD4mnfjwkmZ1ZcP/story.html?p1=ArticleTab_Article_Top July 27, 2014 Up-Regulated LCN2 in PH Involving in PASMC Resistance to Apoptosis http://www.phcentral.org/news/5263 http://www.ijbs.com/v10p0798.htm July 26, 2014 Mustaches May Raise Burn Risk With Home Oxygen Therapy http://www.phcentral.org/news/5262 http://www.medscape.com/viewarticle/828171 July 26, 2014 Making Pulmonary Pressure Measurements Safer For PH Patients Using Ultrasound http://www.phcentral.org/news/5260 http://pulmonaryhypertensionnews.com/2014/07/08/making-pulmonary-pressure-measurements-safer-ph-patients-using-ultrasound/ July 25, 2014