PHCentral RSS - rss http://phcentral.org FIRE feed Mon, 22 Dec 2014 19:12:22 GMT Happy Holidays to All! http://www.phcentral.org/news/5519 December 20, 2014 First results of Russia's national PH registry http://www.phcentral.org/news/5520 http://www.ncbi.nlm.nih.gov/pubmed/25518507 December 19, 2014 Cytori Announces Informational Session on Potential Therapy for Scleroderma http://www.phcentral.org/news/5518 http://pulmonaryhypertensionnews.com/2014/12/19/cytori-announces-informational-session-potential-therapy-scleroderma/ December 19, 2014 The ocular impact of Sildenafil http://www.phcentral.org/news/5517 http://www.opticianonline.net/ocular-impact-viagra/ December 19, 2014 click headline for more

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Interleukin 13– and interleukin 17A–induced pulmonary hypertension phenotype due to inhalation of antigen and fine particles from air pollution http://www.phcentral.org/news/5516 http://www.jstor.org/stable/10.1086/678511 December 18, 2014

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A bunch of exciting free fulltext PH-aticles from PVRI http://www.phcentral.org/news/5515 http://www.jstor.org/stable/10.1086/678133 December 17, 2014 The first annual Drug Discovery and Development Symposium for Pulmonary Hypertension http://www.phcentral.org/news/5514 http://www.jstor.org/stable/10.1086/679063 December 17, 2014 [..]
A "must read" article for interested PH patients, click headline
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Acute hemodynamic response of infused fasudil in patients with pulmonary arterial hypertension: A randomized, controlled, crossover study. http://www.phcentral.org/news/5513 http://www.ncbi.nlm.nih.gov/pubmed/25499341 December 17, 2014 GlaxoSmithKline seeks expanded hypertension approval for Volibris http://www.phcentral.org/news/5510 http://www.zenopa.com/news/801765845/glaxosmithkline-seeks-expanded-hypertension-approval-for-volibris December 16, 2014 The Year in Medicine 2014: News That Made a Difference http://www.phcentral.org/news/5512 http://www.medscape.com/features/slideshow/public/year-in-medicine2014?src=wnl_edit_specol&uac=74933DY#1 December 16, 2014 A predictive model of the effects of depression, anxiety, stress, 6-minute-walk distance, and social support on health-related quality of life in an adult pulmonary hypertension population. http://www.phcentral.org/news/5511 http://www.ncbi.nlm.nih.gov/pubmed/25469437 December 16, 2014 GSK Seeks European Approval for Ambrisentan as PAH Combination Therapy http://www.phcentral.org/news/5509 http://pulmonaryhypertensionnews.com/2014/12/15/gsk-seeks-european-approval-for-ambrisentan-as-pah-combination-therapy/ December 15, 2014 Silence Therapeutics To Utilize New Genetic Toolkit For PAH Drug Development http://www.phcentral.org/news/5508 http://pulmonaryhypertensionnews.com/2014/12/12/silence-therapeutics-studies-pah-as-part-of-new-drug-development-program/ December 13, 2014 FDA Postmarket Trial for PAH Treatment Bosentan Reveals Drug Does Not Reduce Time To Mortality Rates http://www.phcentral.org/news/5507 http://pulmonaryhypertensionnews.com/2014/04/11/fda-postmarket-trial-pah-treatment-bosentan-reveals-drug-reduce-time-mortality-rates/ December 12, 2014 Actelion European MAA for PAH Drug Selexipag Pending Approval http://www.phcentral.org/news/5506 http://pulmonaryhypertensionnews.com/2014/12/04/actelion-european-maa-for-pah-drug-selexipag-pending-approval/ December 11, 2014 ...
According to a report published June 2014, Selexipag reduced the risk of morbidity/mortality in PAH patients by 39 percent, compared to those who received a placebo. Treatment response was consistent across patient subgroups (age, gender, WHO Functional Class, PAH etiology and background PAH therapy) treated for up to 4.2 years.]]>
STAT5a/b Gene May Be Responsible for Gender Differences in Pulmonary Hypertension http://www.phcentral.org/news/5505 http://pulmonaryhypertensionnews.com/2014/12/08/stat5ab-gene-may-be-responsible-for-gender-differences-in-pulmonary-hypertension/ December 10, 2014 ...
The STAT a/b gene may control the severity of pulmonary hypertension and could be controlled by estrogen levels. This could explain why women do not get as severe pulmonary hypertension as men.
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New Clinical Trial Tests Ambrisentan in Preventing SSc-PAH http://www.phcentral.org/news/5504 http://pulmonaryhypertensionnews.com/2014/12/02/new-clinical-trial-tests-ambrisentan-preventing-ssc-pah/ December 9, 2014 Researchers Uncover New Insights Into Vascular Receptor Autoantibodies in PAH Associated with SSc http://www.phcentral.org/news/5503 http://pulmonaryhypertensionnews.com/2014/09/18/vascular-receptor-autoantibodies-pulmonary-arterial-hypertension-associated-systemic-sclerosis/ December 8, 2014 Noninvasive PAH diagnosis on the horizon http://www.phcentral.org/news/5502 http://www.medwirenews.com/38/106051/Cardiology/Noninvasive_PAH_diagnosis_on_the_horizon.html December 7, 2014 New Clinical Trial Tests Ambrisentan in Preventing SSc-PAH http://www.phcentral.org/news/5501 http://pulmonaryhypertensionnews.com/2014/12/02/new-clinical-trial-tests-ambrisentan-preventing-ssc-pah/ December 7, 2014 Eight Parameters Recommended to Monitor for PH in JSSc Patients http://www.phcentral.org/news/5500 http://pulmonaryhypertensionnews.com/2014/11/28/eight-parameters-recommended-to-monitor-for-ph-in-jssc-patients/ December 7, 2014 The Flavonoid Quercetin Reverses Pulmonary Hypertension in Rats http://www.phcentral.org/news/5499 http://www.plosone.org/article/info:doi/10.1371/journal.pone.0114492 December 6, 2014 Researchers Discover Protein That Can Prevent Pulmonary Hypertension-Related Heart Failure http://www.phcentral.org/news/5498 http://pulmonaryhypertensionnews.com/2014/11/26/researchers-discover-protein-that-can-prevent-pulmonary-hypertension-related-heart-failure/ December 6, 2014 Plos One.]]> Prevalence, Determinants, and Prognostic Significance of Pulmonary Hypertension in Elderly Patients Admitted with Acute Decompensated Heart Failure: A Report from the BIO-HF Registry. http://www.phcentral.org/news/5497 http://www.ncbi.nlm.nih.gov/pubmed/25470753 December 5, 2014 Gene assosiated with gender differences in experimental PAH in mice fould http://www.phcentral.org/news/5496 http://www.ncbi.nlm.nih.gov/pubmed/25470773 December 4, 2014 CYP2C9 gene associated with bosentan-induced liver injury http://www.phcentral.org/news/5495 http://www.healio.com/hepatology/liver-injury-regeneration/news/online/{002b864e-6713-449b-be1f-f6d3625aaae8}/cyp2c9-gene-associated-with-bosentan-induced-liver-injury December 3, 2014 Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats. http://www.phcentral.org/news/5494 http://www.internationaljournalofcardiology.com/article/S0167-5273(14)02342-0/abstract December 3, 2014 PH Diagnosis, Treatment Aided By New Right Ventricle 4D RV-Function Imaging Systems http://www.phcentral.org/news/5489 http://lungdiseasenews.com/2014/12/01/ph-diagnosis-treatment-aided-by-new-right-ventricle-4d-rv-function-imaging-systems/ December 2, 2014 ACTELION SUBMITS SELEXIPAG (UPTRAVI) FOR EMA MARKETING AUTHORISATION IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION http://www.phcentral.org/news/5493 http://www.actelion.com/en/our-company/news-and-events.page?newsId=1875871&bb=js December 1, 2014 ACTELION SUBMITS SELEXIPAG (UPTRAVI) FOR EMA MARKETING AUTHORISATION IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION http://www.phcentral.org/news/5492 http://www.actelion.com/en/our-company/news-and-events.page?newsId=1875871&bb=js December 1, 2014 Identification of treatment goals in paediatric pulmonary arterial hypertension http://www.phcentral.org/news/5488 December 1, 2014
From the identified set of baseline predictors, the variables World Health Organization functional class (WHO-FC), N-terminal pro-brain natriuretic peptide (NT-proBNP) and tricuspid annular plane systolic excursion (TAPSE) were identified as follow-up predictors in which treatment-induced changes were associated with survival. Patients in whom these variables improved after treatment showed better survival (p<0.002).

Therefore, WHO-FC, NT-proBNP and TAPSE are not only predictors of transplant-free survival in paediatric PAH but can also be used as treatment goals, as treatment-induced improvements in these variables are associated with improved survival. The identification of these variables allows for the introduction of goal-oriented treatment strategies in paediatric PAH.]]>
Patients With Reactive Pulmonary Hypertension Present Higher Mortality Risk http://www.phcentral.org/news/5487 http://pulmonaryhypertensionnews.com/2014/11/21/patients-with-reactive-pulmonary-hypertension-present-higher-mortality-risk/ November 30, 2014 Boehringer Ingelheim’s Nintedanib for IPF Receives Positive Opinion http://www.phcentral.org/news/5486 http://pulmonaryhypertensionnews.com/2014/11/24/boehringer-ingelheims-nintedanib-for-ipf-receives-positive-opinion/ November 30, 2014 Proteomics of pulmonary hypertension: could personalized profiles lead to personalized medicine? http://www.phcentral.org/news/5485 http://www.ncbi.nlm.nih.gov/pubmed/25408474 November 30, 2014 Surgical Cure for CTEPH Available in Vanderbilt Medical Center http://www.phcentral.org/news/5484 http://lungdiseasenews.com/2014/11/24/surgical-cure-for-cteph-available-in-vanderbilt-medical-center/ November 29, 2014 Pentraxin3 in Chronic Thromboembolic Pulmonary Hypertension: A New Biomarker for Screening from Remitted Pulmonary Thromboembolism http://www.phcentral.org/news/5483 http://www.plosone.org/article/info:doi/10.1371/journal.pone.0113086?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:+plosone/PLoSONE+(PLOS+ONE+Alerts:+New+Articles) November 29, 2014 miR-29a-3p Attenuates Hypoxic Pulmonary Hypertension by Inhibiting Pulmonary Adventitial Fibroblast Activation http://www.phcentral.org/news/5482 http://hyper.ahajournals.org/content/early/2014/11/24/HYPERTENSIONAHA.114.04600.abstract?cited-by=yes&legid=hypertensionaha;HYPERTENSIONAHA.114.04600v1 November 29, 2014 Why drying washing indoors can pose a serious health threat http://www.phcentral.org/news/5481 https://www.journalism.co.uk/press-releases/why-drying-washing-indoors-can-pose-a-serious-health-threat/s66/a563286/ November 28, 2014 Arena Pharma granted patent for pulmonary hypertension drug http://www.phcentral.org/news/5480 http://www.sddt.com/news/article.cfm?Sourcecode=20141125tqa&_t=Arena+Pharma+granted+patent+for+pulmonary+hypertension+drug#.VHXwQGd0wgM November 27, 2014 SSc-PAH Patients Demonstrate Endothelial-to-Mesenchymal Transition http://www.phcentral.org/news/5479 http://pulmonaryhypertensionnews.com/2014/11/25/ssc-pah-patients-demonstrate-endothelial-to-mesenchymal-transition/ November 26, 2014 Researchers Report Thymosin Beta 4 is Cardioprotective in Pulmonary Hypertension/Heart Failure Model http://www.phcentral.org/news/5478 http://pipelinereview.com/index.php/2014112556165/Proteins-and-Peptides/Researchers-Report-Thymosin-Beta-4-is-Cardioprotective-in-Pulmonary-Hypertension/Heart-Failure-Model.html November 25, 2014 Long-term Benefit With Stem-Cell Transplant in Scleroderma http://www.phcentral.org/news/5477 http://www.medpagetoday.com/MeetingCoverage/ACR/48768 November 24, 2014 New Pulmonary Fibrosis Diagnostic Tool Would Be Faster & Quicker http://www.phcentral.org/news/5476 http://pulmonaryhypertensionnews.com/2014/11/18/new-pulmonary-fibrosis-diagnostic-tool-faster-quicker/ November 23, 2014 Lung Transplantation Decisions For Scleroderma Patients Should Be Rethought, Study Says http://www.phcentral.org/news/5475 http://pulmonaryhypertensionnews.com/2014/11/17/lung-transplantation-decisions-for-scleroderma-patients-should-be-rethought-study-says/ November 23, 2014