PHCentral RSS - rss http://phcentral.org FIRE feed Mon, 29 Aug 2016 03:08:41 GMT Arginase Inhibition Reverses Endothelial Dysfunction, Pulmonary Hypertension, and Vascular Stiffness in Transgenic Sickle Cell Mice http://www.phcentral.org/news/6332 https://meta.science/paper/27537757_arginase_inhibition_reverses_endothelial_dysfunction_pulmonary_hypertension_and_vascular_stiffness_in_transgenic September 3, 2016 Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension http://www.phcentral.org/news/6331 http://www.internationaljournalofcardiology.com/article/S0167-5273(16)31948-9/fulltext?rss=yes September 2, 2016 Endothelin receptor antagonists for persistent pulmonary hypertension in term and late preterm infants http://www.phcentral.org/news/6330 http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD010531.pub2/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+3rd+September+2016+at+08.30+BST/+03:30+EDT/+15:30+SGT+for+5+hours+and+Sunday+4th+September+at+10:00+BST/+05:00+EST/+17:00+SGT+for+1+hour++for+essential+maintenance.+Apologies+for+the+inconvenience September 1, 2016 Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension http://www.phcentral.org/news/6329 http://www.jci.org/articles/view/86387 August 31, 2016 New Understanding of Pulmonary Hypertension Leads to Promising Drug Targets http://www.phcentral.org/news/6328 http://www.upmc.com/media/NewsReleases/2016/Pages/new-ph-drug-targets.aspx August 30, 2016 Journal of Clinical Investigation, highlight the use of these drugs to alter vessel stiffness and its downstream control of metabolism, a link previously unknown for people suffering from the progressive disease.]]> Experts seek origin of pulmonary hypertension to design treatment http://www.phcentral.org/news/6327 http://triblive.com/news/healthnow/10973922-74/hypertension-disease-pulmonary August 30, 2016 Journal of Clinical Investigation, he outlines how two compounds, known as verteporfin and CH-839, show promise in impeding the chain of events that leads from initial stiffness in the arteries to changes in metabolism to heart failure. Doctors have used the compounds to treat cancer and macular degeneration, an eye disease.]]> Blocking a Stress-response Protein Found to Treat PH in Animal Model http://www.phcentral.org/news/6325 http://pulmonaryhypertensionnews.com/2016/08/16/ph-in-animals-treated-by-blocking-stress-response-protein/ August 29, 2016 2 Possible New Treatments for Pulmonary Hypertension ID’d in Study http://www.phcentral.org/news/6326 http://pulmonaryhypertensionnews.com/2016/08/25/new-pulmonary-hypertension-treatments-identified-by-researchers August 29, 2016 Phase 2 Trial Recruiting Scleroderma Patients with PAH in Test of Rituxan http://www.phcentral.org/news/6324 http://pulmonaryhypertensionnews.com/2016/08/18/Clinical-Trial-to-Explore-Rituxan-for-Scleroderma-Linked-PAH-Recruiting-in-the-US August 26, 2016 Riociguat (Adempas): not for use in patients with pulmonary hypertension associated with idiopathic interstitial pneumonias http://www.phcentral.org/news/6318 https://www.gov.uk/drug-safety-update/riociguat-adempas-not-for-use-in-patients-with-pulmonary-hypertension-associated-with-idiopathic-interstitial-pneumonias August 25, 2016 Babies with Down Syndrome May Be at Risk of PAH Before Birth http://www.phcentral.org/news/6323 http://pulmonaryhypertensionnews.com/down-syndrome-babies-at-risk-of-pah-before-birth August 24, 2016 Findings Associated with Pulmonary Hypertension: CT Angiography Based Study http://www.phcentral.org/news/6317 http://file.scirp.org/Html/4-1780281_69542.htm August 24, 2016 Dual-energy CT imaging of pulmonary hypertension http://www.phcentral.org/news/6316 http://blog.smw.ch/dual-energy-ct-imaging-of-pulmonary-hypertension/ August 24, 2016 Actelion (ALIOF) Uptravi Approved for PAH in Switzerland http://www.phcentral.org/news/6322 https://www.yahoo.com/news/actelion-aliof-uptravi-approved-pah-122912351.html August 23, 2016 PhaseBio Announces Dosing of First Patients in Two-Part Phase 2a Study of PB1046 in Cardiopulmonary Disorders http://www.phcentral.org/news/6315 http://www.pharmiweb.com/pressreleases/pressrel.asp?ROW_ID=178384#.V7MB5tQrLWc August 23, 2016 ]]> Study Identifies Link Between Antidepressants and Newborn Hypertension http://www.phcentral.org/news/6321 http://www.madinamerica.com/2016/08/study-identifies-link-between-antidepressants-and-newborn-hypertension/ August 22, 2016 Discovery of infants' airway microbiomes may help predict lung disease http://www.phcentral.org/news/6314 http://medicalxpress.com/news/2016-08-discovery-infants-airway-microbiomes-lung.html August 22, 2016 Blocking a Stress-response Protein Found to Treat PH in Animal Model http://www.phcentral.org/news/6320 http://pulmonaryhypertensionnews.com/2016/08/16/ph-in-animals-treated-by-blocking-stress-response-protein/ August 19, 2016 Breathing problems? Summer makes it worse http://www.phcentral.org/news/6313 http://www.gastongazette.com/entertainment/20160805/your-health-breathing-problems-summer-makes-it-worse August 19, 2016 Reata Releases Update on Clinical Program, Including Phase 2 Study in PH and PAH Patients http://www.phcentral.org/news/6319 http://pulmonaryhypertensionnews.com/Reata-Update-on-PH-and-PAH-Study-Other-Clinical-Work August 18, 2016 Elderly Hospital Patients Arrive Sick, Often Leave Disabled http://www.phcentral.org/news/6312 http://www.medpagetoday.com/Geriatrics/GeneralGeriatrics/59594 August 18, 2016 Statins May Boost Efficacy of Rho-Kinase Inhibitors in Pulmonary Arterial Hypertension http://www.phcentral.org/news/6311 http://pulmonaryhypertensionnews.com/statins-as-pah-treatment-may-boost-rho-kinase-inhibitor+ August 17, 2016 Endothelin-1 Levels Seen as Risk Marker for Pulmonary Hypertension in African-Americans http://www.phcentral.org/news/6310 http://pulmonaryhypertensionnews.com/2016/08/08/Endothelin-1-Levels-Identify-Pulmonary-Hypertension-Risk-Groups-Among-African-Americans August 16, 2016 New, Simplified Testing Method for Rare Genetic Mutations Enhances Diagnosis and Treatment of Pulmonary Hypertension http://www.phcentral.org/news/6309 http://www.einnews.com/pr_news/338388233/new-simplified-testing-method-for-rare-genetic-mutations-enhances-diagnosis-and-treatment-of-pulmonary-hypertension August 15, 2016 Orenitram Tablets Again Found to Be Viable Treatment Option for Stable PAH Patients http://www.phcentral.org/news/6308 http://pulmonaryhypertensionnews.com/Orenitram+Tablets+Again+Found+to+Be+Viable+Treatment+Option+for+Stable+PAH+Patients+ August 12, 2016 Ex-Smokers With COPD Have Persistent Endothelial Distress http://www.phcentral.org/news/6307 Medpage Today August 11, 2016 Teaming Up to Treat Pulmonary Emboli Clotbusters Illustrates Potential of Coordinated Response Programs http://www.phcentral.org/news/6304 http://www.cardiovascularbusiness.com/topics/vascular-endovascular/teaming-treat-pulmonary-emboli-clotbusters-illustrates-potential-coordinated-response-programs August 10, 2016 Persistent severe pulmonary hypertension strong predictor of post-TAVR mortality http://www.phcentral.org/news/6306 http://www.healio.com/cardiac-vascular-intervention/transcatheter-aortic-valve-replacement/news/online/{3ca8936f-0b71-4962-8119-e7105bc2bad6}/persistent-severe-pulmonary-hypertension-strong-predictor-of-post-tavr-mortality August 9, 2016 Research to improve treatment for millions of lung disease patients http://www.phcentral.org/news/6305 http://medicalxpress.com/news/2016-08-treatment-millions-lung-disease-patients.html August 8, 2016 Elevated plasma endothelin-1 levels may predict poor outcomes in black adults http://www.phcentral.org/news/6303 http://www.healio.com/cardiology/vascular-medicine/news/online/{18706360-7086-4865-ba8c-b03483d46afd}/elevated-plasma-endothelin-1-levels-may-predict-poor-outcomes-in-black-adults August 8, 2016 Inhibiting a Specific Molecular Chaperone May Help Treat PAH http://www.phcentral.org/news/6302 http://pulmonaryhypertensionnews.com/2016/08/02/inhibition-heat-shock-protein-90-may-help-treat-pulmonary-arterial-hypertension/ August 5, 2016 Constitutively active form of natriuretic peptide receptor 2 ameliorates experimental pulmonary arterial hypertension http://www.phcentral.org/news/6300 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934588/ August 5, 2016 4 Things Not to Say to Someone with Pulmonary Hypertension http://www.phcentral.org/news/6301 http://pulmonaryhypertensionnews.com/blog/2016/08/01/4-things-not-to-say-to-someone-with-pulmonary-hypertension/ August 4, 2016 Inhibition of heat shock protein 90 improves pulmonary arteriole remodeling in pulmonary arterial hypertension http://www.phcentral.org/news/6299 http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path;[]=10855&path;[]=34364 August 4, 2016 Mitochondrial transplantation attenuates hypoxic pulmonary hypertension http://www.phcentral.org/news/6298 http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path;[]=10596&path;[]=33476 August 3, 2016 Harnessing the Immune System to Fight Cancer http://www.phcentral.org/news/6297 http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html?emc=edit_th_20160731&nl=todaysheadlines&nlid=50221187&_r=0 August 2, 2016 Critical role of tumor necrosis factor receptor 1 in the pathogenesis of pulmonary emphysema in mice http://www.phcentral.org/news/6296 https://www.dovepress.com/critical-role-of-tumor-necrosis-factor-receptor-1-in-the-pathogenesis--peer-reviewed-article-COPD August 1, 2016